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KMID : 0942820120110010057
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Journal of Korean Brain Tumor Society
2012 Volume.11 No. 1 p.57 ~ p.61
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Neoplastic Meningitis of Breast Cancer in the Patient with a Pineocytoma, Mimicking Presentation of Leptomeningeal Dissemination of a Malignant Pineal Tumor
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Jang Ji-Hwan
Kim Kyu-Hong
Yang Geun-Young
Kim Young-Zoon
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Abstract
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Neoplastic meningitis is a relatively rare, but serious late-stage complication of brain metastasis from systemic cancer. A 37-year-old woman presented with complaints of altered mentation, nausea and vomiting. Computed tomography (CT) and magnetic resonance imaging of brain revealed a patchy enhancement with gadolinium contrast of leptomeninges over the cerebral convexities and in basilar cistern, insulae, all the recesses, and ventricular walls. By neuroendoscopy, we performed third ventriculostomy and biopsy of pineal mass, which revealed a histopathologically-pure pineocytoma. The unexpected observation of cells floating in the ventricle was consistent with adenocarcinoma. In systemic work up, Cancer Antigen (CA) 15-3 was markedly increased in serum, and multiple enhanced masses were found in the breast, lung, axial lymph node, and vertebrae on positron emission tomography-CT. Ultrasonography-guided biopsy of breast mass suggested poorly differentiated adenocarcinoma. Herein, we report a rare case of neoplastic meningitis of breast cancer in the patients with a pineocytoma.
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KEYWORD
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Brain metastasis, Breast cancer, Neoplastic meningitis, Pineocytoma
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